南方汉族人群ABCG2 rs2231142和SLC2A9 rs3733591 单核苷酸多态性与高尿酸血症及心血管危险因素的相关性
网络出版日期: 2023-04-10
基金资助
梅州市人民医院科研培育项目（编号：PY⁃C2020034）
Association of ABCG2 rs 2231142 and SLC2A9rs 3733591 gene polymorphisms with hyperuricemia in Southern Han population
Department of Cardiovascular Medicine，Meizhou People′ s Hospital，Meizhou 514031， China
Online published: 2023-04-10
王贤方 刘志东 张园 黄常镜 张海飞 余丽琼 钟炜 . 南方汉族人群ABCG2 rs2231142和SLC2A9 rs3733591 单核苷酸多态性与高尿酸血症及心血管危险因素的相关性 [J]. 实用医学杂志, 2023 , 39(7) : 875 -880 . DOI: 10.3969/j.issn.1006⁃5725.2023.07.015
Objective To investigate the association between ABCG2 rs2231142，SLC2A9 rs3733591， hyperuricemia（HUA）and cardiovascular risk factors. Methods HUA patients and healthy people were admitted to two hospitals. All patients were selected to detect various index indexes，extract DNA and detect genotypes. Results The levels of BMI，sCr，TG and LDL in HUA group were higher than those in normal group（P < 0.05）. The frequency of ABCG2 alleles was higher in the HUA group than in the control group；UA was strongly associated with these two SNPs（P < 0.05）；however，ABCG2 rs 2231142 was also associated with cardiovascular risk factors （P < 0.05），and there were gender differences. Conclusion ABCG2 rs2231142 and SLC2A9rs 3733591 single nucleotide polymorphisms are associated with susceptibility to hyperuricemia，and cardiovascular risk factors have a combined effect on sUA levels.
Key words：
hyperuricemia
/
| 〈 |
|
〉 |