目的 探索 P1⁃HNF4α、CDX2 与慢性胃炎不同临床病理资料的关系及二者之间的相互关系。方法 对 294 例慢性胃炎标本进行 CDX2、P1⁃HNF4α 免疫组化染色，结合慢性胃炎的不同临床 病理资料进行分析。结果 CDX2 和 P1⁃HNF4α 蛋白表达阳性率和表达强度，在肠化生慢性胃炎组织 中要高于非肠化生组织（均 P < 0.001）。在非肠化生组织，P1⁃HNF4α 的表达强度和慢性胃炎的不同 严重程度呈正相关（rs = 0.366，P < 0.001）。141 例 14C⁃尿素呼气试验结果显示男性 HP 感染阳性率明 显高于女性（P = 0.02）。在非肠化生标本组，CDX2 的表达强度在 HP 感染阳性组均要高于 HP 感染阴性组（P = 0.017）。在轻、中、重不同程度慢性胃炎组织中，CDX2 和 P1⁃HNF4α 二者之间的表达强度都 呈现正相关关系（均 rs > 0.5，均 P < 0.001）。按年龄分组，CDX2 的表达在≥ 40 岁年龄组，阳性率高于 < 40 岁年龄组（P = 0.026）。按性别分组，CDX2 的表达强度在男性组中要高于女性组（P = 0.023）。 按部位分组，CDX2 和 P1⁃HNF4α 的阳性率在幽门部+胃角部最高，其他部位（贲门部+胃底部+胃体 部）较低（均 P < 0.001）。除此之外，CDX2 和 P1⁃HNF4α 的表达强度在幽门部+胃角部均高于其他部 位（均 P < 0.05）。结论 在慢性胃炎的部分临床病理特征中，P1⁃HNF4α 与 CDX2 的表达具有相同 的共性，且二者之间存在正相关关系，因此推测二者在慢性胃炎发生发展过程中可能共同发挥着重要作用。

Objective To explore the relationship between P1⁃HNF4α，CDX2 and the different clinical and pathological data of chronic gastritis. Methods 294 chronic gastritis samples were stained with CDX2 and P1⁃ HNF4α and analyzed with different clinical and pathological data of chronic gastritis. Results In the intestinal metaplasia group，the total positive rate and expression intensity of CDX2 and P1⁃HNF4α were higher than those in the nonintestinal metaplasia group（all P < 0.001）. In the non⁃intestinal metaplasia group，the expression intensity of P1⁃HNF4α expression and the severity of chronic gastritis were positively correlated（rs = 0.366，P < 0.001）. 141 cases of Carbon⁃14 urea breath test showed that the positive rate of HP infection in men was significantly higher than that in women（P = 0.02）. In the non⁃intestinal metaplasia group，the expression intensity of CDX2 was higher in the H. pylori positive group than in the H. pylori negative group（P = 0.017）. In different degrees of chronic gastritis，the expression intensity between CDX2 and P1⁃HNF4α showed a positive correlation（all rs > 0.5，all P < 0.001）. By age group，the total positive rate of CDX2 was higher in ≥ 40 years old group（P = 0.026）. By sex group，CDX2 expression intensity was higher in male than in female group（P = 0.023）. By site group，the total positive rate of CDX2 and P1⁃HNF4α was highest in the pylorus and gastric corner，while the other sites（cardia + gastric base + gastric body）were relatively lower（both P < 0.001）. In addition，the expression intensity of CDX2and P1⁃HNF4α was higher in the pyloric and gastric corners than in the other sites（both P < 0.05）. Conclusion In some clinicopathological features of chronic gastritis，the expression of P1⁃HNF4 α and CDX2 have the same commonness，and there is a positive correlation between P1⁃HNF4 α and CDX2. It is speculated that they may both play an important role in the development of chronic gastritis.