大细胞肺癌（large cell lung carcinoma，LCLC）是一种未分化的非小细胞肺癌，其病理特征缺 乏腺癌、鳞癌和小细胞癌的细胞形态、组织结构及免疫标记物。LCLC 发病率低且预后差。LCLC 占肺癌 手术标本不超过 1%。全身综合治疗是其主要的治疗方式。本文结合近年来国内外关于 LCLC 病理诊断 和治疗方面的研究进展进行综述，为下一步研究和治疗提供参考方向。

Large cell lung carcinoma（LCLC）is an undifferentiated non⁃small cell lung cancer that lacks the morphological and immunological markers of adenocarcinoma，squamous cell carcinoma，and small cell carci⁃ noma. LCLC has a low incidence and poor prognosis. The incidence of LCLC is less than 1% of lung cancer surgical specimens. Systemic comprehensive treatment is the main treatment. This article reviews the research progress in the pathological diagnosis and treatment of LCLC in recent years，aiming to provide a reference for further research and treatment.