肺癌仍是高发病率和高病死率的恶性肿瘤之一，随着新一代测序技术的发展，人体微生态与肺 癌的相互关系已成为研究热点。目前越来越多的证据表明微生物细菌群落与包括肺癌在内的恶性肿瘤的发 生发展相关，但其相互作用机制仍不明确，本文将人体口腔、肠道、肺部的细菌微生态与肺癌的相关研究予以 综述，旨在为临床上诊断与治疗肺癌提供新的思路，同时对人体微生态与肺癌的今后研究方向提出展望。

Lung cancer remains one of the most deadly malignant tumors，with a high morbidity and mor⁃ tality rate. The interrelationship between human microbiota and lung cancer has become a hot spot for research with the development of next⁃generation sequencing technology. There is increasing evidence that microbiota are associ⁃ ated with the development of malignant tumors，including lung cancer，but their interaction mechanisms are still unknown. This paper reviews studies on microbiota and lung cancer in humans，including the oral cavity，intes⁃ tine，lung，with the goal of providing new ideas for the clinical diagnosis and treatment of lung cancer，as well as an outlook on the future research direction of human microbiota and lung cancer.