目的 分析骨质疏松症（osteoporosis，OP）患者外周血微小核糖核酸⁃141（micromolecule ribo⁃ nucleic acid⁃141，miR⁃141）表达，并分析其对骨折风险的预测价值。方法 选取 175 例在河南省中医院 治疗的 OP 患者记为研究组，同时招募 156 例同年龄段的健康志愿者记为对照组，均测定外周血 miR⁃141 表达，并对研究组随访 1 年。结果 研究组男性、女性外周血 miR⁃141 表达均高于对照组（P < 0.05）；研究 组骨折发生率 30.29%，高于对照组的 7.05%（P < 0.05），研究组女性、男性骨折发生率分别高于对照组 （P < 0.05）；miR⁃141 表达预测 OP 男性、女性患者骨折风险的曲线下面积（AUC）分别为 0.968（95%CI： 0.895 ~ 0.996）、0.726（95%CI：0.631 ~ 0.808）。结论 OP 患者的外周血 miR⁃141 表达升高，且对骨折风险 预测效能高。

Objective To investigate the changes in the peripheral blood micromolecule ribonucleic acid⁃ 141（miR⁃141）in osteoporosis（OP）patients，as well as its predictive value for fracture risk. Methods 175 hospitalized OP patients in He′nan Hospital of Traditional Chinese Medicine were chosen as the study group，and 156 healthy volunteers of the same age were recruited as the control group. The expression of miR⁃141 was detected， and the study group was followed up for 1 year. Results The expressions of miR ⁃141 of men and women in the study group were higher than those of the control group（P < 0.05）. The study group had a fracture rate of 30.29%， compared to 7.05% in the control group（P < 0.05）. Fractures were more common in women and men in the study group than in the control group（P < 0.05）. The area under the curve（AUC）of miR⁃141 expression in predicting fracture risk in male and female patients with OP were 0.968（95%CI：0.895 ~ 0.996）and 0.726（95%CI：0.631 ~ 0.808），respectively. Conclusion MiR ⁃141 expression is comparatively higher in OP patients，and it is also highly effective in predicting fracture risk.