As a common neurological disease，epilepsy has the characteristics of recurrent seizures and unpredictability. Single and conventional monitoring means，such as EEG，have limited effect on the prediction or treatment guidance of epilepsy. Therefore，the combination of new means can further predict or guide its treatment. As an emerging technology，brain microdialysis technology can monitor changes such as chemical concentration in the brain，which can predict the seizures of epilepsy to a certain extent，and can study the mechanism behind its occurrence，which plays a certain guiding role in treatment. This paper reviews the current brain microdialysis tech⁃ nology，miniaturized sampling probe，optogenetics combined with brain microdialysis technology with improved time resolution，aiming to provide new ideas for the detection of cranial neurochemicals in seizures.