脓毒症是宿主对感染反应失调导致的多器官功能障碍，发病机制复杂，死亡率高，治疗困难。连续性肾脏替代治疗包括多种血液净化模式，通过对脓毒症患者中炎症介质和细胞因子的清除、血流动力学障碍的改善及器官功能的保护，提高患者生存率。本文就连续性肾脏替代治疗（continuous renalreplacement therapy，CRRT）各种治疗模式及相关血滤器和膜材对治疗脓毒症的优缺点做一综述。

Sepsis is defined as life⁃threatening organ dysfunction caused by a dysregulated host response toinfection. With complicated pathogenesis and high mortality，it is intractable to treat. Continuous renal replacementtherapy（CRRT）is an umbrella term of long⁃time continuous extracorporeal blood purification which was practicedfor replacing injured kidney function but CRRT has been set for bringing critically ill patients out of danger. Theeffect on improving survival rate of CRRT treating sepsis is embodied in clearing inflammatory mediators andcytokines，improving hemodynamic disorder and protecting organ function. This review focuses on the advantagesand disadvantages of various CRRT treatment modes，related blood filters and membrane materials in the treatmentof sepsis.