三羧酸循环到有氧糖酵解的代谢转换是肿瘤细胞代谢的重要特征之一，丙酮酸脱氢酶激酶 4（PDK4）在多数癌细胞中的表达明显增加，作为促进这种代谢转换的关键分子，PDK4 通过调节丙酮酸脱 氢酶活性，在多种肿瘤细胞的增殖、侵袭与转移、凋亡和耐药中起到关键作用。越来越多的研究发现 PDK4 与肺癌发展和耐药联系密切。本文通过对 PDK4 在恶性肿瘤中的研究进行综述和展望，以期对肿瘤 尤其是非小细胞肺癌的预防、治疗和逆转耐药提供一定的思路。

Compared with normal cells，tumor cells are more inclined to switch from the Krebs cycle to aerobic glycolysis. PDK4 acts as a bridge in this metabolic transition，and its expression is up ⁃ regulated in most cancer cells. Pyruvate dehydrogenase activity can be regulated by this kinase，which in turn affects various biologi⁃ cal characteristics of tumor cells. In addition，studies on PDK4 and lung cancer development，and drug resistance continue to emerge. This article hopes to provide some ideas for the reversal of tumor resistance，especially NSCLC，by reviewing the research on PDK4 and malignant tumors.