目的 探讨可乐定透皮贴剂联合维生素 D3 滴剂治疗儿童抽动障碍的临床疗效及对血清 25 羟维生素D 水平的影响。方法 选取2020年1月至2022年1月份在长江大学附属第一医院儿童神经专科 门诊就诊的抽动障碍患儿 115 例，随机分为可乐定透皮贴剂+维生素 D3 滴剂组 43 例、可乐定透皮贴剂组 41 例和维生素 D3 滴剂组 31 例。治疗前和治疗后 4、12 周比较 3 组耶鲁综合抽动严重程度量表（YGTSS）评 分、血清 1⁃25 羟维生素 D 水平，判断疗效和安全性。结果 与治疗前比较，治疗后 4、12 周三组均较治疗 前 YGTSS 评分降低（P < 0.05）。治疗后4周，可乐定透皮贴剂+维生素D3滴剂组较可乐定透皮贴剂、维生素 D3滴剂组 YGTSS 评分低（P < 0.05）；治疗后 12 周，可乐定透皮贴剂+维生素 D3 滴剂组 YGTSS 评分较其余 两组低（P < 0.05）。治疗 12 周后可乐定透皮贴剂+维生素 D3 滴剂组、维生素 D3 滴剂组血清 25 羟维生素 D 水平均较治疗前升高（P < 0.05）。结论 可乐定透皮贴剂+维生素 D3 滴剂组治疗儿童抽动障碍疗效显 著，维生素D3治疗有一定的临床疗效。

Objective The study was designed to investigate the clinical efficacy of clonidine transdermal patch combined with vitamin D3 drops in the treatment of tic disorder in children and to analyze the relationship between the serum 25 hydroxy vitamin D level and its clinical efficacy. Methods A total of one hundred and fifteen children with tic disorders who attended our pediatric neurology outpatient department from January 2020 to June 2022 were randomly divided into three groups：45 cases in the clonidine transdermal patch+vitamin D3 drops group，45 cases in the clonidine transdermal patch group，and 30 cases in the vitamin D3 drops group. Comparison of Yale General Tic Severity Scale（YGTSS）score and serum 1⁃25 hydroxy vitamin D levels between the three groups of 0，4 and 12 weeks after treatment were made to determine efficacy and safety. Results Compared with pre ⁃treatment，YGTSS scores were lower in all three groups at 4 and 12 weeks of treatment compared with pre ⁃ treatment（P < 0.05）. At 4 weeks after treatment，YGTSS scores were reduced in the clonidine transdermal patch + vitamin D3 drops group and clonidine transdermal patch compared with the vitamin D3 drops group（P < 0.05）. At 12 weeks after treatment，YGTSS scores were lower in the clonidine transdermal patch + vitamin D3 drops group compared with the other two groups（P < 0.05）. Serum 25 hydroxyvitamin D levels were higher in all three groups after 12 weeks of treatment compared with those before treatment（P < 0.05）. Conclusion Clonidine trans⁃ dermal patch + vitamin D3 dr ops group was more effective than other 2 groups in treating tic disorder in chil⁃ dren，and vitamine D may be helpful in the treatment of Tic disorder.