全球非酒精性脂肪性肝病的发病率快速上升，科研工作者对其病因、发病机制、病理生理学、临床诊疗和社会经济等方面的研究和认识也不断深入。2020 年国际专家小组及亚太肝脏研究协会在新版指南中将非酒精性脂肪性肝病正式更名为代谢相关脂肪性肝病。此次概念变更是疾病新认知的第一步，其为临床诊疗及学术研究带来了新的机遇和挑战。本文拟回顾、总结疾病概念变更的起始，进一步

探讨其对临床实践的影响。

With the global incidence of non⁃alcoholic fatty liver disease increasing year by year，the inter⁃national expert group and the Asia⁃Pacific Association for the Study of the Liver have officially changed the name of non ⁃alcoholic fatty liver disease to metabolic associated fatty liver disease in the new guideline for further understanding of its pathogenesis. This conceptual change will bring new opportunities and challenges to clinical diagnosis and treatment and academic research. The aims of this article were to summarize the initiation and further explore of the conceptual change and its impact on clinical practice.