目的 对国内外慢性便秘临床实践指南进行质量评价和内容分析，筛选高质量指南，以期 为今后慢性便秘指南的制定提供借鉴。方法 系统检索国内外数据库和指南网站，收集 2016 年至今发 布的慢性便秘临床实践指南。采用 AGREEⅡ指南评价工具对纳入的指南进行质量评价。主要从慢性 便秘诊断和治疗方面提取、汇总纳入指南的推荐意见。结果 共纳入 19 部国外指南，其中 14 部 B 级指 南，5 部 C 级指南；共筛选 3 部较高质量的指南。AGREEⅡ各领域的标准化得分分别为：表达的明晰性 （78.36%）、范围和目的（62.57%）、制定的严谨性（35.47%）、编辑独立性（33.99%）、参与人员（33.19%）和应 用性（27.85%）。汇总纳入指南有关疾病诊疗的推荐意见共 26 条。结论 慢性便秘实践指南/专家共识总 体质量不高，参与人员、制定的严谨性、应用性和编辑独立性领域亟待完善。指南涵盖的诊疗内容较为全 面，但部分治疗方法存在争议，指南推荐意见尚需进一步完善、统一以优化临床实践。

Objective To evaluate the methodological quality and analysis content of clinical practice guidelines and expert consensus for chronic constipation，and screen high⁃quality guidelines to provide reference for future guidelines. Methods Systematically search domestic and foreign databases and guideline websites for clinical practice guidelines for chronic constipation published since 2016，and evaluate the quality of included guidelines using the guideline evaluation tool AGREE Ⅱ. Results A total of 19 guidelines were included，among which 14 B ⁃level guidelines and 5 C ⁃level guidelines. There were 3 high ⁃ quality guidelines selected，all from abroad. The standardization scores of AGREE Ⅱ in six fields respectively were：clarity of expression（78.36%），scope and purpose（62.57%），preciseness of formulation（35.47%），editorial independence（33.99%），participants（33.19%） and applicability（27.85%）. Totally，26 recommendations on diagnosis and treatment of chronic constipation were summarized. Conclusion The overall quality of the included clinical practice guidelines/expert consensus on chronic constipation is not high，and the areas of participants，rigor，application and editorial independence need to be further improved. The guidelines cover a comprehensive range of treatments，but some are controversial，so guideline recommendations need to be further refined to optimize clinical practice.