生物钟能够广泛调节机体的行为和生理功能，研究发现肠道也具有生物钟节律且受中枢生物钟节律的调控。生物钟节律紊乱现象广泛存在于炎症性肠病、肠易激综合征以及结直肠癌等多种肠道疾病中，与此同时生物钟节律紊乱也会对胃肠道动力、肠道黏膜屏障的通透性以及肠道菌群等产生重要影响，从而引发多种多样的肠道功能紊乱或肠道疾病。本文主要对肠道生物钟节律相关疾病及其机制作一综述。

The biological clock can widely regulate the behavior and physiological function of human body.Studies have found that the intestinal tract itself also has biological clock rhythm and is regulated by the central biological clock rhythm. Circadian rhythm disorders widely relates to inflammatory bowel disease，irritable bowel syndrome，colorectal cancer and other intestinal diseases. Otherwise，biological clock rhythm disorders will also have an important impact on gastrointestinal motility，intestinal mucosal barrier permeability and intestinal flora，resulting in a variety of intestinal dysfunction or intestinal diseases. This paper mainly reviews the relationship of intestinal biological clock rhythm with the diseases and its mechanism.