无论是内源性还是获得性化疗耐药，都已成为神经胶质瘤治疗的主要障碍。众所周知，胶 质瘤化疗耐药是由多种机制相互作用导致的。所以，充分了解化疗耐药的潜在机制，开发新的治疗靶点 来克服耐药，对于改善胶质瘤患者的预后至关重要。令人振奋的是，越来越多的证据表明，长链非编码 RNA（long non⁃coding RNA，lncRNA）可以通过靶向作用各种调控机制来介导胶质瘤的发生发展和耐药 性。本综述系统地阐述了 lncRNA 在胶质瘤耐药调控中的分子机制，并讨论了 lncRNA 作为胶质瘤耐药标 志物和新型治疗靶点的潜在功能。旨在通过调节这些特定 lncRNA 来逆转肿瘤细胞的化疗抗性，为胶质 瘤耐药治疗开辟新的研究方向。

Either endogenous or acquired resistance to chemotherapy has become the main obstacles in the treatment of neuroglioma. As is well ⁃ known，glioma chemoresistance is caused by interaction of multiple mecha⁃ nisms. Therefore，sufficient understanding of potential mechanism on chemoresistance and development of new treatment targets to eliminate chemoresistance are crucial to the prognosis improvement for glioma patients. It is inspiring that more and more evidence has indicated that long non⁃coding RNA（lncRNA）mediated occurrence， development and chemoresistance of glioma via targeting at various regulation mechanisms. This review has systemi⁃ cally clarified the molecular mechanism of lncRNA in the regulation of glioma chemoresistance and has discussed the potential function of lncRNA as a marker of glioma chemoresistance and a novel treatment target. It aims at developing novel research direction for glioma chemoresistance treatment by regulating these specific lncRNAs to reverse chemoresistance of tumor cells.