Rheumatic immune disease is a chronic inflammatory autoimmune disease mainly affecting joints，bones，muscles and so on. At present，traditional slow ⁃ acting antirheumatic drugs and biological agents play an active role in the treatment of the disease，but for some cases，the therapy with the drugs or agents cannot achieve continuous remission or only maintain a low activity of the disease because of poor therapeutic efficacy or drug intolerance. Therefore，the development of new therapy is of great benefit to such patients with poor response. As a new type of cellular immunotherapy，CAR⁃T therapy shows a good clinical effect in the treatment of hematolog⁃ical malignant tumors. With its mechanism，it also brings hope for the treatment of rheumatic immune diseases such as RA，SLE，SSc and so on，but it leads to some side effects such as cytokine storm，increased infection

rate，neurotoxicity and so on. This paper has systematically reviewed the literature on CAR⁃T therapy for some rheu⁃matic immune diseases in order to provide a new insight into the application of CAR⁃T therapy in the treatment of rheumatic immune diseases in the future.