肺缺血再灌注损伤是指在多种原因导致的肺脏缺血的基础上，恢复肺脏血流灌注后肺组织损伤加重的现象，其发病率和病死率都很高。在肺缺血再灌注损伤引起肺组织炎症反应中，其自噬活性随疾病特点及发展阶段而发生变化。因此，深入探讨炎症与自噬的关系，对维持细胞自噬稳态，改善缺血再灌注所导致的肺损伤具有重要的意义。本文综述了炎症和自噬及其交互作用对肺组织缺血再灌注的调控机制，旨在为肺缺血再灌注损伤的诊疗及预后改善等提供参考。

Lung ischemia reperfusion injury（LIRI）refers to the aggravation of lung tissue injury after lung perfusion is restored on the basis of lung ischemia caused by various reasons，with high morbidity and mortality. In the inflammatory response of lung tissue caused by LIRI，there are changes in autophagy activity according to the different characteristics and development stages of the disease. Therefore，in⁃depth study of the relationship between autophagy and inflammation is of great significance for maintaining autophagy homeostasis and improving lung injury caused by ischemia⁃reperfusion. This paper reviews the regulatory mechanisms of inflammation，autoph⁃ agy and their interaction on LIRI，aiming to provide reference for the diagnosis，treatment and prognosis of LIRI.