目的 探讨壳聚糖蜂胶复合材料联合 PRP（自体富血小板血浆）在骨科非急性感染性创面 中的临床效果。方法 收集 2020 年 1 月至 2021 年 10 月，我院骨科收治的 60 例四肢非急性感染性创面患 者，数字随机法分为 A 组（壳聚糖蜂胶治疗组 20 例）、B 组（壳聚糖 PRP 治疗组 20 例）和 C 组（壳聚糖蜂胶 PRP 复合材料治疗组 20 例）三组，并评估治疗 3、6、9、12 d 后疼痛、生活质量评分，并对创面愈合时间、愈 合面积、治疗前后炎性指标进行比较分析。结果 治疗前后三组患者疼痛、生活质量评分均具有明显改 善（P < 0.05）；治疗后 C 组愈合时间明显短于 A 组和 B 组（P < 0.05）；治疗 9 d 后 C 组愈合面积优于 A 组和 B 组（P < 0.05）；治疗 12 d 后 C 组患者 C 反应蛋白、白细胞计数改善率明显优于 A 组和 B 组（P < 0.05）。 结论 PRP 联合壳聚糖蜂胶复合材料在骨科非急性感染性创面中应用可有效抗菌，加快创面愈合，减轻 患者疼痛感和提高患者生活质量。

Objective To investigate the clinical effect of PRP（autologous platelet⁃rich plasma）combined with chitosan probe composite on non⁃acute infectious wounds of orthopedic patients. Methods From September 2020 to July 2021，60 patients with non⁃acute infectious wounds on limbs admitted to the orthopedics department of our hospital were randomly divided by digital random method into groups A，B and C treated with chitosan propolis， chitosan PRP and chitosan propolis PRP composite，respectively，20 in each. The scores of pain，anxiety and quality of life after 3，6，9 and 12 days of treatment were evaluated. The wound healing time，healing area and inflammatory indexes before and after treatment were compared and analyzed. Results The scores of pain，anxiety and quality of life in three groups were significantly improved after treatment（P < 0.05）. The healing time of group C was significantly shorter than that of group A and group B（P < 0.05）. After 6 days treatment，the healing area of group C was significantly larger than those of group A and group B（P < 0.05）. After 12 days treatment，the improvement rate of C⁃reactive protein and white blood cell count in group C was significantly higher than those in group A and group B（P < 0.05）. Conclusion PRP combined with chitosan propolis composite material can effectively fight against bacteria，accelerate wound healing，relieve pain and improve the quality of life in orthopedic patients with non⁃acute infectious wounds.