实用医学杂志 ›› 2021, Vol. 37 ›› Issue (8): 1037-1045.doi: 10.3969/j.issn.1006⁃5725.2021.08.014

• 临床研究 • 上一篇    下一篇

鼻咽癌原发肿瘤MRI⁃DWI 联合体积预测鼻咽部放化疗近期疗效

方楠, 张俊安, 孙俊旗,张相国, 陈冬平,郑露,邓颖, 杨展昕,董恩来,齐斌    

  1. 1 广州医科大学附属肿瘤医院放疗科(广州510095);汕头大学附属粤北人民医院2 影像科, 3 放疗科(广东韶关512026)

  • 出版日期:2021-04-25 发布日期:2021-04-25
  • 通讯作者: 齐斌 E⁃mail:qibin020@126.com
  • 基金资助:
    广 东 省 医 学 科 学 技 术 研 究 基 金 项 目(编 号 :B2019159)

Prognostic value of diffusion ⁃weighted MRI combine with tumor volume for the short ⁃ term treatment response ofnasopharynxin nasopharyngeal carcinoma

FANG Nan,ZHANG Jun′ an,SUN Junqi,ZHANG Xiangguo,CHEN Dongping,ZHENG Lu,DENG Ying,YANG Zhanxin,DONG Enlai,QI Bin.   

  1. Department of Radiotherapy,Affiliated Cancer Hospital&Institute of Guangzhou Medical University,Guangzhou 510095,China

  • Online:2021-04-25 Published:2021-04-25
  • Contact: QI Bin E⁃mail:qibin020@126.com

摘要:

目的 探讨鼻咽癌原发肿瘤 MRI⁃DWI 联合体积对鼻咽部放化疗近期疗效的预测价值。方法 纳入 94 例鼻咽癌病例,获得治疗前鼻咽肿物 ADC 值及体积。治疗结束后根据 RESIET 1.1 评估放化疗疗效,分为完全缓解(CR)组和非 CR 组。分析原发肿瘤 ADC 值、肿瘤体积及二者联合用于预测鼻咽部放化疗近期疗效的价值。结果 治疗前 CR 组、非 CR 组的原发肿瘤 ADC 值和体积差异有统计学意义;ADC 值、单纯原发肿瘤体积和原发肿瘤体积+咽后淋巴结体积的 AUC 分别为 0.656、0.678 0.699,治疗前原发肿瘤 ADC 值、原发肿瘤体积+咽后淋巴结体积二者联合后的 AUC 0.772;将原发肿瘤 ADC 值与原发肿瘤体积+咽后淋巴结体积纳入构建 nomogram,C 指数为 0.770。结论 鼻咽癌原发肿瘤体积联合 MRI 弥散成像ADC 值可用于鼻咽部放化疗近期疗效的预测。

关键词:

Abstract:

Objective To investigate the prognostic value of diffusion⁃weighted(DW)MRI combine tumor volume for the treatment response of nasopharynx in nasopharyngeal carcinoma(NPC). Methods 94 patientswith NPC were enrolled ,ADC value and tumor volume of nasopharynx was recorded before treatment. Patients were divided into complete remission(CR)group and non CR group according to treatment response,the predic⁃ tive ability of tumor volume and ADC value and their combination was analyzed. Results The pretreated value of ADC,gross tumor volume of nasopharynx(GTVnx)and GTVnx with retropharyngeal lymph nodes(GTVnx+RLN showed statistical difference between CR group and non CR group. AUC of ADC,GTVnx and GTVnx+RLN were 0.656,0.678 and 0.699 respectively. AUC reached 0.772 when we combined ADC value with GTVnx+RLN. We further incorporated ADC value and GTVnx + RLN by constructing nomogram,C ⁃index were 0.770. Conclusion The combination of pretreated ADC value and GTVnx+RLN can be used to predict the treatment response in NPC.

Key words:

nasopharyngeal carcinoma, diffusion?weighted imaging, tumor volume, retropharyngeal lymph nodes