实用医学杂志 ›› 2023, Vol. 39 ›› Issue (6): 724-729.doi: 10.3969/j.issn.1006⁃5725.2023.06.012

• 临床研究 • 上一篇    下一篇

药物涂层球囊在自体动静脉瘘狭窄治疗中的应用 

李越 王兵 牛晓阳 刘文江 高士钦 丁亚坤    

  1. 郑州大学第五附属医院血管外科(郑州 450052)

  • 出版日期:2023-03-25 发布日期:2023-03-25
  • 通讯作者: 王兵 E⁃mail:hnxgwk@126.com
  • 基金资助:
    河南省医学科技攻关计划省部共建基金资助项目(编号:2018010012)

Application of drug⁃coated balloon in treatment of arteriovenous fistula stenosis

LI Yue,WANG Bing,NIU Xiaoyang,LIU Wenjiang,GAO Shiqin,DING Yakun.   

  1. Department of Vascular Surgery,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China

  • Online:2023-03-25 Published:2023-03-25
  • Contact: WANG Bing E⁃mail:hnxgwk@126.com

摘要:

目的 评估药物涂层球囊(drug coated balloon,DCB)治疗自体动静脉瘘狭窄的中短期临床效果。方法 回顾性分析 2020 5 月至 2021 12 月腔内治疗 43 例自体动静脉瘘狭窄患者的临床资料, 22 例行药物涂层球囊治疗(DCB 组),21 例行普通球囊治疗(PAB 组),术后对比两组 3、6、12 个月靶病变一 期通畅率(TLPP)、循环通路一期通畅率(ACPP)、晚期管腔丢失(LLL)等指标。结果 所有病例手术均获 成功,术后 3 个月两组 TLPP 差异无统计学意义,术后 6、12 个月 DCB 组的 TLPP PAB 组明显提高 [(81.8% vs. 47.6%)、(54.5% vs. 23.8%),均 P < 0.05],术后 3、6、12 个月两组的 ACPP 差异无统计学意义;术 DCB 6、12 个月 LLL 明显低于 PAB 组(P < 0.05)。结论 药物涂层球囊治疗自体动静脉瘘的中短期临 床效果较好,对比普通球囊优势显著。

关键词:

血液透析, 自体动静脉瘘狭窄, 经皮腔内血管成形术, 药物涂层球囊

Abstract:

Objective To evaluate the short⁃ and medium⁃term efficacy of drug⁃coated balloon(DCB)in the treatment of arteriovenous fistula stenosis. Methods The clinical data of 43 patients with arteriovenous fistula stenosis treated with endovascular therapy from May 2020 to December 2021 were retrospectively analyzed. Twenty⁃ two patients were treated with DCB(DCB group),and 21 patients with plain angioplasty balloon(PAB group). Target lesion primary patency(TLPP),access circuit primary patency(ACPP),late lumen loss(LLL)and other indicators were compared between the two groups at 3,6,12 months after operation. Results The operation was successful in all cases. There was no significant difference in TLPP between the two groups 3 months after opera⁃ tion. The TLPP of DCB group was significantly higher than that of PAB group 6 and 12 months after operation [(81.8% vs. 47.6%),(54.5% vs. 23.8%),both P < 0.05)];there was no significant difference in ACPP between the two groups 3,6,12 months after operation;LLL 6 and 12 months after operation in DCB group was significant⁃ ly lower than that in PAB group(P < 0.05). Conclusion DCB has a better clinical efficacy and significant advan⁃ tage over plain angioplasty balloon in the treatment of arteriovenous fistula.

Key words:

hemodialysis, arteriovenous fistula stenosis, percutaneous transluminal angioplasty, drug coated balloon