实用医学杂志 ›› 2022, Vol. 38 ›› Issue (23): 2968-2972.doi: 10.3969/j.issn.1006⁃5725.2022.23.014

• 临床研究 • 上一篇    下一篇

不同绒毛膜性质三胎妊娠减一胎的临床结局 

崔媛媛1 叶德盛2 谭颖1 马从顺1 詹雪君1 宋革1    

  1. 1 广东省生殖医院生殖医学中心(广州510600);2 广州市妇女儿童医疗中心生殖医学中心(广州510623)

  • 出版日期:2022-12-10 发布日期:2022-12-10
  • 通讯作者: 宋革 E⁃mail:songgepp@126.com
  • 基金资助:
    广东省医学科学技术研究基金(编号:A2020060)

Clinical outcomes of multifetal pregnancy reduction in triplet pregnancy with different chorionic proper⁃ ties

CUI Yuanyuan*,YE Desheng,TAN Ying,MA Congshun,ZHAN Xuejun,SONG Ge.   

  1. Department of Repro⁃ ductive Medicine,Guangdong Provincial Fertility Hospital,Guangzhou 510600,China

  • Online:2022-12-10 Published:2022-12-10
  • Contact: SONG Ge E⁃mail:songgepp@126.com

摘要:

目的 分析不同绒毛膜性质三胎妊娠减灭一胎的有效性和可行性方法 回顾性分析33 经辅助生殖技术治疗获三胎妊娠,且孕 6 ~ 10 周行经阴道减胎术患者,其中 14 例双绒毛膜三羊膜囊 dichorionic⁃triamniotic,DCTA)三胎妊娠为DCTA组,19例三绒毛膜三羊膜囊(trichorionic⁃triamniotic,TCTA 三胎妊娠为 TCTA 组。通过病例资料匹配选择同期获双绒毛膜双羊膜囊(dichorionic⁃diamniotic,DCDA)双 胎妊娠且未行减胎术的患者 60 例作为 DCDA 组。比较三组患者的临床妊娠结局、妊娠期并发症和新生 儿情况。结果 所有减胎患者术中均保留双胎,无减胎失败病例。减胎术后 1 d,DCTA 组有 10 例(71.4% 出现单绒毛膜双羊膜囊(monochorionic⁃diamniotic,MCDA)保留胎儿自然减灭,TCTA 组无自然减胎,差异 有统计学意义(P < 0.05)。术后 1 周至孕晚期,三组自然减胎和自然流产的发生率差异均无统计学意义 P > 0.05)。DCTA 组单胎活产率(75%)及平均分娩孕周[(38.3 ± 2.2)周],均显著高于 TCTA 组[5.3% 36.6 ± 1.7)周]和 DCDA 组[17.5%,(37.1 ± 1.7)周,P < 0.05]。结论 孕早期三胎妊娠行减胎术减灭一胎 安全可行。DCTA 三胎妊娠减灭其中 MCDA 双胎之一,另一保留胚胎发生自然减胎几率增加。故需充分 告知减胎术,尤其是减灭其中MCDA 双胎之一的相关风险。

关键词: 胎减胎术; , 三胎妊娠; , 妊娠结局; , 安全性

Abstract:

Objective To analyze the effectiveness and feasibility of selective multifetal pregnancy reduc⁃ tion(MFPR)in triplet pregnancy with different chorionic properties. Methods A total of 33 patients obtaining triplet pregnancy with different chorionic properties by assisted reproductive technology and undergoing selective MFPR in the Department of Reproductive Medicine,Guangdong Provincial Fertility Hospital were retrospectively analyzed,including 14 dichorionic⁃triamniotic(DCTA)triplet pregnancies and 19 trichorionic⁃triamniotic(TCTA triplet pregnancies. Sixty dichorionic⁃diamniotic(DCDA)twin pregnancies without MFPR were collected as con⁃ trols. The pregnancy outcomes,pregnancy complications,and neonatal status were compared among the three groups. Results All thepatients undergoing selective MFPR were successful to have DCDA twin pregnancy after the procedure. Spontaneous pregnancy reduction occurred in 10 DCTA triplet pregnancies(10/14,71.4%)but not in TCTA anytriplet pregnancy(0/19,0.0%)one day aftertheprocedure. The difference between the two groups was statistically significant(P < 0.05). There were no significant differences in the rates of spontaneous pregnancy reduction and spontaneous abortion among three groups(P > 0.05). The singleton live birth rate and gestational weekat delivery were significantly higher in the DCTA triplet pregnancy group[75%,(38.3 ± 2.2)weeks]than in the TCTA triplet pregnancy and DCDA twin pregnancy groups[5.3%,(36.6 ± 1.7)weeks;17.5%,(37.1 ± 1.7)weeks)](P < 0.05). Conclusions Selective MFPR for patients with DCTA or TCTA triplet pregnancy is safeand feasible. Reduction of one MCDA fetal in patients with DCTA triplet pregnancy might significantly increase spontaneous pregnancy reduction rateinthe other MCDA fetal. The patients with triplet pregnancy should be fully informed the relevantrisk of MFPR,especially those with DCTA triplet pregnancy undergoing reduction of one MCDA fetal.

Key words:

multifetal pregnancy reduction, triplet pregnancy, pregnancy outcome, safety