实用医学杂志 ›› 2022, Vol. 38 ›› Issue (21): 2720-2726.doi: 10.3969/j.issn.1006⁃5725.2022.21.016

• 临床研究 • 上一篇    下一篇

急性前壁心肌梗死患者急诊经皮冠脉介入术后主动脉内球囊反搏与重组人脑利钠肽对心功能的保护作用

马贵洲 徐荣和 周琳洁 蔡志雄 郑海生 郭海森 许志浩 陈钢彬 倪楚民 王莹   

  1. 汕头市中心医院心内科(广东汕头 515031)

  • 出版日期:2022-11-10 发布日期:2022-11-10
  • 基金资助:
    2019 年汕头市第六批医疗卫生科技计划项目(编号:汕府科[2020]5 号-8)

Combined application of IABP and rhBNP in patients with acute anterior ST⁃segment elevation myocardial infarction undergoing emergency percutaneous coronary intervention

MA Guizhou,XU Ronghe,ZHOU Linjie,CAI Zhixiong,ZHENG Haisheng,GUO Haisen,XU Zhihao,CHEN Gangbin,NI Chumin,WANG Ying.   

  1. Department of Cardiology,Shantou Central Hospital,Shantou 515031,China

  • Online:2022-11-10 Published:2022-11-10

摘要:

目的 探讨急性前壁心梗患者在急诊冠脉介入(PCI)的基础上,联合应用主动脉内球囊反搏(IABP)与重组人脑利钠肽(rhBNP)对心功能的影响。方法 分析2019年8月至2020年12月入住汕头市中心医院 CCU 并接受急诊 PCI 的急性前壁心肌梗死患者,根据应用 IABP、rhBNP 情况分为三组:A 组采用IABP 联合 rhBNP,B 组仅采用 IABP,C 组仅采用 rhBNP。分析三组之间的心功能、心肌酶指标、平均住院日、住院及随访期间不良事件。结果(1)三组患者血 cTNI 峰值、血 CKMB 峰值差异无统计学意义(P >0.05);但血 NT⁃proBNP 峰值差异有统计学意义(P < 0.05);其中 A 组的血 NT⁃proBNP 峰值低于 B 组与 C 组(P < 0.05);(2)三组患者入院 24 h 内左室舒张末内径(LVDD)及左室射血分数(LVEF)差异无统计学意义(P > 0.05);而在出院后 6 个月,A 组的 LVDD 较 B 组、C 组均缩小,差异有统计学意义(P < 0.05)。另外,A组患者在出院后 6 个月的 LVDD 较基线水平缩小且 LVEF 升高,差异有统计学意义(P < 0.05),而 B 组及C 组出院后 6 个月的 LVDD 及 LVEF 与基线水平比较差异无统计学意义(P > 0.05)。(3)三组患者平均住院日及住院期间不良事件比较差异无统计学意义(P > 0.05);(4)随访期间发生需住院的心衰:A 组为 1 例(2.17%)、B 组为 5 例(17.86%)、C 组为 1(5.88%),三组间存在差异有统计学意义(P < 0.05);但在再次血运重建方面差异无统计学意义(P > 0.05)。结论 对于急性前壁心肌梗死行急诊PCI患者,联合应用IABP与rhBNP 可抑制左心室重构、改善心功能,并降低出院后发生需住院心衰概率。

关键词: 急性 , ST 段抬高型心肌梗死, 急诊经皮冠脉介入术, 主动脉内球囊反搏, 重组人脑利钠肽


Abstract:

Objective To investigate the effects of IABP in combination with rhBNP in patients undergo⁃ ing emergency percutaneous coronary intervention(PCI)for acute anterior myocardial infarction. Methods The study included 91 patients who had an acute anterior myocardial infarction and needed emergency PCI. They were divided into three groups based on the application of IABP and rhBNP:group A received IABP combined with rhBNP,group B received IABP,and group C received rhBNP. Cardiac function index,average length of stay adverse events during hospitalization and post⁃discharge follow⁃up were all examined. Results (1)the peak NT⁃proBNP concentration in group A was lower than that in group B and C(P < 0.05).(2)There were no significant differences in LVDD or LVEF among the three groups at admission(P > 0.05). During the follow ⁃up,LVDD in group A was smaller than that in group B and group C(P < 0.05). In addition,compared with baseline,the LVDD decreased and LVEF increased in group A at 6 months after discharge(P < 0.05). However,there were no statistical differences in LVDD and LVEF between groups B and C when compared to baseline(P > 0.05).(3)During hospital⁃ ization,the average length of stay and adverse events did not differ statistically(P > 0.05).(4)During the follow⁃up period,the incidence of heart failure requiring hospitalization was 2.17% in group A,17.86% in group B,and5.88% in group C,and the difference was statistically significant(P < 0.05). However,there was no significant difference in revascularization among the three groups(P > 0.05). Conclusion The combination of IABP and rhBNP can improve cardiac function and reduce the incidence of heart failure requiring hospitalization after dis⁃ charge in patients with acute anterior STEMI undergoing emergency PCI.

Key words:

text-indent:0pt, "> sssacute st?segment elevation myocardial infarction,  , emergency percutaneous coronary inter? vention,  , intra?aortic balloon counterpulsation,  , recombinant human brain natriuretic peptide