实用医学杂志 ›› 2022, Vol. 38 ›› Issue (10): 1286-1291.doi: 10.3969/j.issn.1006⁃5725.2022.10.022

• 综述 • 上一篇    下一篇

腹膜透析腹膜纤维化防治研究进展

万静芳 陈客宏   

  1. 陆军军医大学大坪医院肾内科(重庆 400000)

  • 出版日期:2022-05-25 发布日期:2022-05-25
  • 通讯作者: 陈客宏 E⁃mail:chenkehong@foxmail.com
  • 基金资助:
    国家自然科学基金项目(编号:81770731);重庆市技术创新与应用发展专项面上项目(编号 :cstc2019jscx ⁃ msx⁃mX0258)

Progress on preventing peritoneal fibrosis in peritoneal dialysis

WAN Jingfang,CHEN Kehong.   

  1. Department of Nephrology,Army Specialty Medical Center,Army Military Medical University,Chongqing 400000,China

  • Online:2022-05-25 Published:2022-05-25
  • Contact: CHEN Kehong E⁃mail:chenkehong@foxmail.com

摘要:

腹膜透析(peritoneal dialysis,PD)具有保护残肾功能等诸多优势,已成为肾脏替代治疗的主 流方式之一。长期腹膜透析导致腹膜透析腹膜纤维化是患者退出 PD 主要原因,且目前防治方案相对有 限。许多学者针对腹膜透析腹膜纤维化进行了不断的探索与研究,笔者对近期腹膜透析腹膜纤维化的研 究新进展进行了综述,从抑制慢性炎症、抑制腹膜新生血管、抑制促纤维化因子分泌、暂停腹膜透析、基因 治疗、干细胞治疗等方面总结了防治腹膜透析腹膜纤维化的新方法,旨在为腹膜透析腹膜纤维化防治相 关研究提供参考。

关键词:

腹膜透析, 腹膜纤维化, 防治措施, 研究进展

Abstract:

Peritoneal dialysis(PD)is one of the main methods of renal replacement therapy because of its advantages in protecting residual renal function. Peritoneal fibrosis caused by long ⁃term peritoneal dialysis is the main reason for PD withdrawal. The strategy of prevention of peritoneal fibrosis is still limited. Many scholars have carried out continuous exploration and research on peritoneal dialysis. We reviewed the recent progress of peritoneal fibrosis in peritoneal dialysis. This paper summarizes the new methods for preventing and treating peritoneal fibrosis in peritoneal dialysis,including inhibiting chronic inflammation,inhibiting peritoneal neovascularization,inhibit⁃ ing the secretion of fibrogenic factors,improving the biocompatibility of peritoneal dialysate,suspending peritoneal dialysis and gene therapy. The purpose is to provide reference for the prevention of peritoneal fibrosis on peritoneal dialysis.

Key words:

peritoneal dialysis,  , peritoneal fibrosis,  , interventions,  , research progress