关键词: 特发性中枢性性早熟, 维生素D, 糖脂代谢, 促黄体生成素, 促卵泡刺激素

Abstract:

Objective To analyze gonadotropin level，lipid metabolism，vitamin D and insulin resistanceindex of girls with idiopathic central precocious puberty，and analyze the correlation of these indexes with bodymass. Methods A total of 111 cases of girls admitted to our hospital with precocious puberty were selected anddivided into control group consisting of 51 patients with simple early breast development and observation group of60 cases with idiopathic central precocious puberty. Height，weight，secondary sex characteristic，the determinationof fasting plasma glucose（FPG），fasting insulin（FINS），triglyceride（TG），cholesterol（CHO），insulin⁃likegrowth factor 1（IGF⁃1），25⁃（OH）D3，luteinizing hormone（LH），follicle stimulating hormone（FSH），FSH peaklevel，LH peak level，and calculate the body mass index（BMI），insulin resistance index（HOME⁃IR），LH peak/FSH peak were tested and analyzed. The differences of gonadotropin level，lipid metabolism，vitamin D，HOME⁃IRbetween two groups were compared，and the correlation analysis of the above indexes was also conducted. Results In the observation group，BMI was positively correlated with LH ，LH peak level /FSH peak level（r = 0.476 and0.470 respectively，P < 0.05），and negatively with vitamin D（r = -0.290，P < 0.05）. IGF⁃1 was positively correlatedwith LH，TG，LH peak value，LH/FSH，IHOME⁃IR and BMI（r = 0.553，0.355，0.351，0.459，0.531 and 0.330respectively，P＜0.05）. LH was positively correlated with HOME⁃IR，BMI，IGF⁃1（r = 0.320，0.476 and 0.553respectively，P＜0.05），and negatively with vitamin D（r = -0.266，P＜0.05）. HOME⁃IR was positively correlatedwith LH，TG，LH peak level /FSH peak level and IGF⁃1（r = 0.320，0.298，0.430 and 0.531 respectively，P＜0.05）. Vitamin D deficiency was found in 39 of 51 girls in the control group and in 46 of 60 girls in the observation group. Conclusion Glucolipid metabolism in girls with idiopathic central precocious puberty may be affected bysex hormone levels. Vitamin D deficiency and increased BMI are important factors for girls in their early sexualdevelopment.

Key words: idiopathic central precocious puberty（ICPP）, vitamin D, glucolipid metabolism, lu?teinizing hormone（LH）, follicle stimulating hormone（FSH）