实用医学杂志 ›› 2025, Vol. 41 ›› Issue (12): 1767-1774.doi: 10.3969/j.issn.1006-5725.2025.12.001

• 专题笔谈 •    

耳廓重建仿生假体材料工程化构建研究进展

王云云1,张海军2,3,张立2,王秀1,常谨3()   

  1. 1.河北工程大学临床医学院 (河北 邯郸 056038 )
    2.同济大学医学院 (上海 200331 )
    3.河北工程大学附属医院整形外科 (河北 邯郸 056000 )
  • 收稿日期:2025-02-27 出版日期:2025-06-25 发布日期:2025-07-02
  • 通讯作者: 常谨 E-mail:cjls818717@sina.com
  • 作者简介:常谨,副主任医师,医学硕士,整形外科硕士研究生导师,医疗美容整形外科副主任, 中华医学会整形外科分会唇腭裂学组委员、中国整形美容协会精准鼻整形委员会委员、河北省医师协会美容与整形分会常务委员、河北省整形美容协会委员、河北省医保专家库评审专家。该学科获河北省重点专科,邯郸市重点学科。
  • 基金资助:
    国家重点研发计划“诊疗装备与生物医用材料”重点专项2024年度项目(2024YFC24210200)

Research progress on the engineering construction of biomimetic auricle reconstruction prosthesis

Yunyun WANG1,Haijun ZHANG2,3,Li ZHANG2,Xiu WANG1,Jin CHANG3()   

  1. Clinical Medical College,Hebei University of Engineering,Handan 056038,Hebei,China
  • Received:2025-02-27 Online:2025-06-25 Published:2025-07-02
  • Contact: Jin CHANG E-mail:cjls818717@sina.com

摘要:

生物材料为修复耳部缺损,特别是小耳畸形,提供了一种可靠且安全的治疗手段。在跨学科研究的不断推动下,耳廓重建所用材料的种类与性能得到了极大的拓展与提升。该文全面综述了高分子材料以及组织工程支架在耳廓重建领域的最新研究进展,深入探讨了这些支架在体外及体内环境下的物理化学性能以及临床应用效果。然而,尽管耳支架研究取得了显著进展,当前的高分子材料的应用仍然存在一些挑战和局限性,如高密度聚乙烯的疏水性及组织工程中干细胞分化的不可控性。因此,该文探讨了新型改性材料的研究与临床中的应用,特别是强调了表面改性技术和创新合成策略的重要性,使改性材料的性能无限接近人耳软骨的特性。此外,该文还总结了耳软骨组织工程中干细胞分化的控制方法。对不同耳支架的应用性能及生物相容性进行综述,以期为耳廓重建提供指导。

关键词: 耳廓重建, 耳支架, 组织工程, 生物材料

Abstract:

Biomaterials provide a reliable and safe treatment for the repair of ear defects, especially microtia. With the continuous promotion of interdisciplinary research, the types and properties of materials used in auricle reconstruction have been greatly expanded and improved. In this paper, the latest research progress of polymer materials and tissue engineering scaffolds in the field of auricle reconstruction was reviewed, and the physical and chemical properties and clinical application effects of these scaffolds in vitro and in vivo were discussed. However, despite significant progress in ear stent research, there are still some challenges and limitations in the application of current polymer materials, such as the hydrophobicity of high-density polyethylene and the uncontrolled differentiation of stem cells in tissue engineering. Therefore, this paper discusses the research and clinical application of new modified materials, especially emphasizing the importance of surface modification technology and innovative synthesis strategies, so that the properties of modified materials are infinitely close to the characteristics of human ear cartilage. In addition, this paper also summarizes the control methods of stem cell differentiation in ear cartilage tissue engineering. The application performance and biocompatibility of different ear scaffolds were reviewed in order to provide guidance for auricle reconstruction.

Key words: auricle reconstruction, ear support, tissue engineering, biomaterial

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