静息态功能磁共振成像在颞叶癫痫认知损害中的研究进展

doi:10.3969/j.issn.1006-5725.2024.20.022

摘要/Abstract

摘要：

颞叶癫痫作为常见的癫痫类型之一，其反复发作可能导致患者认知功能的受损，但其确切机制尚未明确。近年来，无创性的静息态功能磁共振成像技术备受关注，以其高时空分辨率，广泛应用于颞叶癫痫认知损害研究。该文以颞叶癫痫为研究对象，通过综合分析静息态功能性磁共振研究文献，深入探讨了致痫灶的定位和对患者大脑功能网络的影响，为颞叶癫痫认知损害机制提供了深入的理解。并且详细探讨了静息态磁共振在手术效果预测和机器学习应用方面的潜力，这不仅有助于提升治疗效果，还为制定治疗方案提供了新的途径，使临床实践更加精准和智能。

关键词: 颞叶癫痫, 认知损害, 功能性磁共振成像

Abstract:

Temporal lobe epilepsy （TLE） is a common type of epilepsy. It may lead to cognitive impairment when it becomes recurrent. However， how it happens remains unclear. Recently， noninvasive resting-state functional magnetic resonance imaging （rs-fMRI） has been used comprehensively in the clinical diagnosis of temporal lobe epilepsy-associated cognitive impairment for its high temporal and spatial resolution. To better understand the effectiveness of rs-fMRI in the diagnosis， his paper reviews the relevant literature， comprehensively analyzing the epileptogenic foci localization and neural network alterations displayed by rs-fMRI and exploring the insight to the mechanism of temporal lobe epilepsy-associated cognitive impairment. Moreover， the paper has discussed the rs-fMRI's potential in predicting surgical outcomes and machine learning applications. This review is hoped to be conducive to improving treatment outcomes and providing novel approaches for more precise and intelligent interventions in clinical practice.

Key words: temporal lobe epilepsy, cognitive impairment, functional magnetic resonance imaging

中图分类号:

R742.1

赵家瑞,龚玉来. 静息态功能磁共振成像在颞叶癫痫认知损害中的研究进展[J]. 实用医学杂志, 2024, 40(20): 2954-2959.

Jiarui ZHAO,Yulai GONG. Effectiveness of resting-state fMRI in the diagnosis of temporal lobe epilepsy-associated cognitive impairment： A review of literature[J]. The Journal of Practical Medicine, 2024, 40(20): 2954-2959.

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