实用医学杂志 ›› 2021, Vol. 37 ›› Issue (23): 2963-2966.doi: 10.3969/j.issn.1006⁃5725.2021.23.001

• 临床新进展 •    下一篇

Ⅲ型干扰素在抗人类免疫缺陷病毒感染中的作用

丁亚1 姚静2 彭小青1 梁辉勇1 苏齐鉴1,3   

  1. 1 广西中医药大学(南宁 530200);2 广西中医药大学附属瑞康医院(南宁 530011);3 钦州市第一人民医院(广西钦州 535000)
  • 出版日期:2021-12-10 发布日期:2021-12-10
  • 通讯作者: 苏齐鉴 E⁃mail:agansue@163.com
  • 基金资助:
    国家自然科学基金项目(编号:81360258);广西中医药大学广西一流学科建设开放课题(编号:2019XK158)

Effect of type Ⅲ interferon on anti⁃HIV infection

DING Ya,YAO Jing,PENG Xiaoqing,LIANG Huiyong,SU Qijian.
  

  1. Guangxi University of Chinese Medicine,Nanning 530200,China
  • Online:2021-12-10 Published:2021-12-10

摘要:

型干扰素由 IFN⁃λ1、IFN⁃λ2、IFN⁃λ3 和新发现的 IFN⁃λ4 组成,与Ⅰ型干扰素激活共同信号 通路,生物活性相似,具有抗病毒、抗肿瘤、抗细胞增殖和免疫调节等作用,在抗 HIV 感染中起重要作用。 最初研究发现白细胞白介素 28B 的基因多态性与丙型肝炎病毒感染者治疗应答及自发清除相关,IL⁃28 因多态性可用来预测 HCV 感染的干扰素治疗效果和临床指导用药,使得该位点成为研究热点。而干扰素 的抗病毒共性也引起了学者关于 IL⁃28 基因多态性与 HIV 感染相关性的关注,近来不少研究发现 IFNL3/4 基因座的遗传变异与艾滋病疾病易感性、抗病毒免疫应答和疾病进程存在相关性,而 IFNL 基因突变原因 及对抗病毒感染的生物学机制尚不清楚。本文就型干扰素的生物活性、抗病毒作用机制、抗 HIV 感染 及其基因多态性位点的相关性研究等方面进行综合论述。

关键词:

型干扰素, HIV, 干扰素, 单核苷酸多态性

Abstract:

Type Ⅲ interferon includes IFN⁃λ1,IFN⁃λ2,IFN⁃λ3 and the newly discovered IFN⁃λ4. It activates a common signal pathway with type I interferon and has similar biological activity. It has anti⁃virus,anti⁃ tumor,anti⁃cell proliferation and immune regulation effects,and plays an important role in anti⁃HIV infection. At first,it was found that the gene polymorphism of interleukin⁃28B is related to the treatment response and spontane⁃ ous clearance of HCV infected patients. This correlation analysis was used to predict the therapeutic effect of inter⁃ feron for HCV infection and guiding clinical medication,which makes the polymorphism site of IL⁃28 gene become a hot spot. The antiviral commonness of interferon has also attracted scholars′ attention on the correlation between IL⁃28 gene polymorphism and HIV infection. Recently,many studies have found that genetic variation of IFNL3/4 locus is also associated with disease susceptibility,antiviral immune response and disease progression of AIDS,but the cause of IFNL mutation and its biological mechanism against viral infection remain unclear. This review summa⁃ rizes the biological activity,antiviral mechanism,anti ⁃ HIV infection and the correlation of gene polymorphism sites of type Ⅲ interferon.

Key words:

type Ⅲ interferon, HIV, interferon?λ, SNPs