仿生矿化胶原改性聚甲基丙烯酸甲酯骨水泥治疗单节段骨质疏松性胸腰椎压缩性骨折的近中期疗效

doi:10.3969/j.issn.1006⁃5725.2021.06.016

实用医学杂志 ›› 2021, Vol. 37 ›› Issue (6): 768-772.doi: 10.3969/j.issn.1006⁃5725.2021.06.016

仿生矿化胶原改性聚甲基丙烯酸甲酯骨水泥治疗单节段骨质疏松性胸腰椎压缩性骨折的近中期疗效

陈峙，蒋顺琬，韦丽丽

1 深圳市中医院骨伤科（广东深圳 518033）；2 南山区医疗集团总部平山社康全科（广东深圳 518055）

出版日期:2021-03-25 发布日期:2021-03-25
基金资助:
广东省中医药局课题（编号：20181228）

Evaluation on short and medium⁃term efficacy of biomimetic mineralized collagen⁃modified PMMA bone cement for osteoporotic compression fractures of thoracolumbar spine

CHEN Zhi，JIANG Shunwan，WEI Lili.

Department of Orthopedic，Shenzhen Traditional Chinese Medicine Hospital，Shenzhen 518033，China

Online:2021-03-25 Published:2021-03-25

摘要/Abstract

摘要：

目的探究仿生矿化胶原改性聚甲基丙烯酸甲酯（polymethyl methacrylate，PMMA）骨水泥治疗单节段骨质疏松性胸腰椎压缩性骨折（osteoporotic vertebral compression fracture，OVCF）的近中期疗效。方法将我院自2017 年 5 月至 2019 年 6 月收治的 120例单椎体骨质疏松性胸腰椎压缩性骨折患者随机分为对照组和治疗组，各60例。对照组采用PMMA 骨水泥行经皮椎体后凸成形，治疗组采用仿生矿化胶原改性 PMMA 骨水泥行经皮椎体后凸成形术。分别于术前及术后2 d、、6 个月记录VAS评分、Oswestry功能障碍指数量表（ODI），测量伤椎矢状面指数、Cobb角、椎体内骨水泥分布情况。结果两组术前与术后2 d、3、6 个月的 VAS 评分、ODI 评分、伤椎矢状面指数、Cobb角差异均有统计学意义，组内术后各观察点比较差异无统计学意义，组间术后同一观察点比较差异无统计学意义。骨水泥渗漏对照组 13 例、治疗组 10 例。对照组术后6 个月出现 2 例再发腰背痛，治疗组未见。结论仿生矿化胶原改性 PMMA 骨水泥治疗单节段骨质疏松性胸腰椎压缩性骨折近中期疗效与单一PMMA 骨水泥相当。

关键词:

仿生矿化胶原, 聚甲基丙烯酸甲酯骨水泥改性, 骨质疏松性压缩性骨折

Abstract:

Objective To explore the short and medium⁃term efficacy of biomimetic collagen⁃modified PM⁃ MA bone cement in the treatment of single segment osteoporotic thoracolumbar compression fractures（OVCF）. Methods 120 patients with single vertebral osteoporotic thoracolumbar compression fractures admitted to our hospital from May 2017 to June 2019 were randomly divided into control group and treatment group，60 for each group. PMMA bone cement was used for percutaneous kyphoplasty in the control group，while biomimetic mineralized collagen ⁃modified PMMA bone cement was used for percutaneous kyphoplasty in the treatment group. VAS score and oswestry disability index scale（ODI）were recorded presurgically and at postsurgical day 2 and months 3 and 6，and sagittal plane index，Cobb Angle and bone cement distribution in the vertebra were measured. Results There were statistical significant differences in VAS score ，ODI score，sagittal plane index and Cobb Angle between the two groups at preoperative and postoperative day 2 and months 3 and 6，while there were no statistical significant differences between the two groups in the postoperative observation time points，and there were no statis⁃ tical significant differences between the two groups in the same postoperative observation time points. 13 patients were in the control group and 10 in the treatment group. Recurrent low back pain occurred in two patients in the control group 6 months after surgery，but not in the treatment group. Conclusions The short and medium⁃term efficacy of biomimetic mineralized collagen ⁃ modified PMMA bone cement is equivalent to that of single PMMA bone cement in the treatment of single segment osteoporotic thoracolumbar compression fracture. The number of complications was less in the treatment group than in the control group，but the difference was not statistically significant，requiring larger sample size and long⁃term observation.

Key words:

biomimetic mineralized collagen, modification of PMMA bone cement, osteoporotic compression fracture

陈峙蒋顺琬韦丽丽.

仿生矿化胶原改性聚甲基丙烯酸甲酯骨水泥治疗单节段骨质疏松性胸腰椎压缩性骨折的近中期疗效 [J]. 实用医学杂志, 2021, 37(6): 768-772.

CHEN Zhi, JIANG Shunwan, WEI Lili..

Evaluation on short and medium⁃term efficacy of biomimetic mineralized collagen⁃modified PMMA bone cement for osteoporotic compression fractures of thoracolumbar spine [J]. The Journal of Practical Medicine, 2021, 37(6): 768-772.

仿生矿化胶原改性聚甲基丙烯酸甲酯骨水泥治疗单节段骨质疏松性胸腰椎压缩性骨折的近中期疗效

Evaluation on short and medium⁃term efficacy of biomimetic mineralized collagen⁃modified PMMA bone cement for osteoporotic compression fractures of thoracolumbar spine

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