Objective To investigate the influencing factors affecting the reproductive outcomes of unexplained infertile couples following intrauterine insemination（IUI），and construct prediction models of their reproductive outcomes. Methods The clinical data of the unexplained infertile couples（female，less than 40 years old）and the anti⁃Mullerian hormone（AMH）levels ≥ 1.1 pg/mL）were retrospectively analysed The primary and secondary outcomes of this study were the live birth rate per cycle and the clinical pregnancy rate per cycle ， respectively. The predictive models of live birth rate and clinical pregnancy rate were constructed using logistic regression，and their accuracies were determined by areas under the receiver operating characteristic curve（AUC）. Results The study included 2601 cycles of IUI for unexplained infertile couples. Univariable regression analyses of the clinical data from the live birth group vs. non live birth group，and from clinical pregnancy group vs. non clinical pregnancy group found that，AMH levels（live birth：OR = 1.06，95%CI：1.02 ~ 1.11，and clinical preg⁃ nancy，OR = 1.05，95%CI：1.01 ~ 1.09）and ovarian stimulation（live birth：OR = 4.74，95%CI：3.48 ~ 6.46，and clinical pregnancy，OR = 4.35，95%CI：3.31 ~ 5.72）had significant impacts on the reproductive outcomes. Predic⁃ tion models with AMH levels and ovulation stimulation could predict the live birth rate and clinical pregnancy rate per cycle with AUC at 0.70（95%CI：0.66 ~ 0.74）for the live birth and at 0.68（95%CI：0.65 ~ 0.72）for the clinical pregnancy. Conclusion Prediction models with ovulation stimulation and AMH levels can predict live birth rate and clinical pregnancy rate of unexplained infertile couples following IUI. Those with high AMH levels and the help of ovarian stimulation could end up with better reproductive outcomes.