关键词:

人软骨糖蛋白39, 肺炎, 相关性, 新生儿

Abstract:

Objective To study the diagnostic value of YKL⁃40，SP⁃A and IL⁃8 combined detection in neonatal pneumonia as well as its significance in determining critical severity. Methods In this study，150 patients with neonatal pneumonia diagnosed in our hospital from January 2017 to January 2021 were selected as the research subjects，including 82 mild patients and 68 severe patients. The control group consisted of another 150 healthy newborns born during the same time period. The levels of YKL⁃40，SP⁃A，and IL⁃8 were compared in the observation group，the control group，and patients of varying severity，and YKL⁃40，SP⁃A and IL⁃8 were analyzed The significance of combined diagnosis in the diagnosis of neonatal pneumonia. Results YKL ⁃40（t = 29.889， P ≤ 0.001）and IL⁃8（t = 26.725，P ≤ 0.001）were significantly higher in the observation group than those of in the control group，while SP⁃A（t = 71.258，P ≤ 0.001）was significantly lower in the observation group than those of in the control group，YKL⁃40（t = 4.171，P ≤ 0.001）and IL⁃8（t = 48.098，P ≤ 0.001）were significantly lower the mild group than those of the control group，and SP⁃A（t = 15.482，P ≤ 0.001）were significantly higher in the observation group than those of the control group；YKL⁃40，SP⁃A，and IL⁃8 effects on neonatal lung cancer，the area under the ROC curve of combined detection was significantly higher than that of single detection，according to the ROC curve analysis. The critical values for YKL ⁃ 40，SP ⁃A and IL ⁃8 were 32.55 ng/mL，4.23 ng/mL and 259.36 ng/mL，respectively，according to the ROC curve analysis. The severity of neonatal pneumonia was found to be negatively correlated with YKL ⁃40 and IL ⁃8，and positively correlated with SP ⁃A using correlation analysis. Conclusion The combination detection of YKL⁃40，SP⁃A，and IL⁃8 is very useful for diagnosing newborn pneu⁃ monia and determining critical severity. 

Key words:

 , YKL?40, pneumonia, relevance, newborn