实用医学杂志 ›› 2021, Vol. 37 ›› Issue (7): 935-938.doi: 10.3969/j.issn.1006⁃5725.2021.07.021

• 医学检查与临床诊断 • 上一篇    下一篇

脐血嗜酸性粒细胞趋化因子水平对早期婴儿湿疹的预测意义

林裕庆,王文革, 唐学武, 谭汉旭, 杨云月   

  1. 1 河北北方学院(河北张家口 075000);2 中国人民解放军空军特色医学中心(北京 100142)

  • 出版日期:2021-04-10 发布日期:2021-04-10
  • 通讯作者: 王文革 E⁃mail:1264516006@qq.com
  • 基金资助:
    北京市科技计划项目⁃首都临床特色应用研究(编号:Z181100001718029)

The significance of umbilical cord blood Eotaxin level in predicting early infant eczema

LIN Yuqing* WANG Wen′ge,TANG Xuewu,TAN Hanxu,YANG Yunyue.   

  1. Hebei North University,Zhangjiakou 075000,Chi⁃ na;Air Force Medical Center,PLA,Beijing 100142,China

  • Online:2021-04-10 Published:2021-04-10
  • Contact: WANG Wen′ge E⁃mail:1264516006@qq.com

摘要:

目的 分析脐血嗜酸性粒细胞趋化因子(Eotaxin)水平的影响因素,探讨脐血 Eotaxin 水平对 42 d 婴儿湿疹的预测意义。方法 采集 188 例新生儿的脐血,应用酶联免疫吸附法测定脐血 Eotaxin 水平,登记新生儿的出生情况及家族过敏史等基本信息,随访 42 d 婴儿的湿疹患病情况。结果 家族有 过敏性疾病史组的新生儿脐血 Eotaxin 水平明显高于家族无过敏性疾病史组(P < 0.05);与无湿疹组比 较,婴儿患有湿疹组脐血 Eotaxin 水平显著升高(P<0.05);根据 logistic 回归分析表明脐血 Eotaxin 高表达 水平、家族过敏史是影响婴儿湿疹患病的独立危险因素(P<0.05);脐血 Eotaxin ROC 曲线的结果为: AUC 0.773,95%CI 0.704 ~ 0.841,特异度为 52.9%,灵敏度为 88.8%。结论 脐血 Eotaxin 高表达水平是影响婴儿湿疹患病的独立危险因素。脐血Eotaxin 水平对婴儿湿疹的发生有一定的预测作用。

关键词:

脐血, 婴儿, 湿疹, 嗜酸性粒细胞趋化因子, 预测意义

Abstract:

Objective To analyze the influencing factors of umbilical cord blood Eotaxin level and explore the predictive significance of umbilical cord blood Eotaxin level in 42⁃day ⁃old infants eczema. Methods The umbilical cord blood was collected from 188 newborns. The level of Eotaxin in umbilical cord blood was determined by enzyme⁃linked immunosorbent assay(Elisa). The birth status and family history of allergies were recorded. The infants were followed up for 42 days. Results The umbilical cord blood Eotaxin level in the family history of allergic disease group was significantly higher than that in the family without allergic disease group,and the umbilical cord blood Eotaxin level in the eczema group was significantly higher than that in the non⁃eczema group(P < 0.05). According to logistic regression analysis,the high expression level of Eotaxin in umbilical cord blood and family history of allergy were important risk factors for infantile eczema. The area under ROC curve(AUC)of umbilical cord blood Eotaxin was 0.773(95%CI:0.704 ~ 0.841),the specificity was 52.9%,and the sensitivity was 88.8%. Conclusion The high expression level of Eotaxin in umbilical cord blood is an independent risk factor for infantile eczema. Umbilical Cord blood Eotaxin level can predict the occurrence of infantile eczema.

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