关键词: 外阴硬化性苔藓, 点阵式CO₂ 激光, 曲安奈德

Abstract:

Objective To investigate the therapeutic efficacy of combining fractional CO₂ laser with triamcinolone acetonide and econazole nitrate cream for the treatment of vulvar lichen sclerosus （VLS）. Methods The clinical data of 113 patients with vulvar lichen sclerosus （VLS） were retrospectively analyzed. The patients were divided into an observation group and a control group based on different treatments received. Clinical symptoms （vulvar itching， painful intercourse） and signs （vulvar skin color， vulvar skin elasticity， range of vulvar lesions） were scored using the Cattaneo scoring criteria. The Cattaneo scores before and after treatment were recorded for each patient， and comparisons were made between groups in terms of Cattaneo scores and occurrence of adverse reactions. The therapeutic efficacy of fractional CO₂ laser combined with triamcinolone acetonide and econazole nitrate cream was evaluated. Results After three treatments， both groups exhibited a significant decrease in Cattaneo scores， with a statistically significant difference （P < 0.05）. The study group demonstrated a significantly greater reduction in Cattaneo scores compared to the control group （P < 0.05）. Furthermore， the cure rate of VSL was higher in the study group than in the control group （25.86% vs. 10.91%， P < 0.05）. Regarding adverse effects， there was no statistically significant difference between the two groups （P > 0.05）. Conclusions Compared to the single application of fractional CO₂ laser， the combination of fractional CO₂ laser with triamcinolone acetonide and econazole nitrate cream demonstrates enhanced efficacy in alleviating signs and symptoms among patients with vulvar sclerosing tundra， while minimizing adverse reactions. This approach holds significant potential for clinical implementation.

Key words: vulvar lichen sclerosus, fractional CO₂ laser, triamcinolone acetonide