关键词:

中枢性性早熟, 雌激素受体α, 雌激素受体β, 基因多态性, 治疗效果

Abstract:

Objective To study the correlation between the effect of Zhibaidihuang pills on central preco⁃ cious puberty in girls and the polymorphism of estrogen receptor（ER）α and β genes. Methods A total of 60 girls with central precocious puberty were selected from the outpatient department of traditional Chinese medicine of Guangdong Province Hospital for Women and Children Healthcare from July 2017 to January 2020. The patients were divided into effective group（n = 60）and ineffective group（n = 20）according to the effect of modified Zhibaidi⁃ huang pills. Polymerise chain reaction⁃restriction fragment length polymorphism（PCR⁃RFLP）was used to analyze the restriction fragment length. Genetic polymorphisms of estrogen receptor α genes Pvu Ⅱ and Xba I and receptor β genes RsaI and AluI were detected in the two groups of girls. Results There was no significant difference in ERα⁃Pvu II and ERα⁃XbaI gene polymorphisms between the effective group and the ineffective group（P > 0.05）. There were significant differences in ERβ RsaI and ERβ Alui gene polymorphisms between the effective group and the invalid group（P < 0.05）. Conclusion The genetic polymorphisms of ERα⁃PvuII and ERα⁃Xba I do not affect the efficacy of the treatment of girls with precocious puberty by modified Zhibaidihuang pills，but the different gene polymorphisms of Erβ⁃RsaI and Erβ⁃AluI do.

Key words:

central precocious puberty, estrogen receptor α, estrogen receptor β, gene polymor? phism, efficacy