丘脑室旁核在全身麻醉机制中的研究进展

doi:10.3969/j.issn.1006-5725.2026.05.022

摘要/Abstract

摘要：

全身麻醉已在临床中广泛应用，但全麻药物导致可逆性意识消失的机制尚未明确。近年来随着神经生物学的快速发展，研究发现丘脑作为感觉信息传递到皮层和皮质-皮层交流的关键枢纽，同时也是上行唤醒系统的重要站点，其在意识中的作用一直是理论研究的重点。大量研究证明室旁丘脑核是丘脑中关键的觉醒核团，其与觉醒相关脑区存在密切的联系。本文系统综述了室旁丘脑核从睡眠-觉醒调节以及全身麻醉致意识消失的神经机制研究进展，为阐明全身麻醉药物调控意识改变的机制提供理论依据。

关键词: 室旁丘脑核, 全身麻醉, 觉醒

Abstract:

General anesthesia is widely used in clinical practice； however， the mechanism through which general anesthetics induce reversible loss of consciousness remains elusive. In recent years， with the rapid development of neurobiology， researchers have identified the thalamus as a key hub， not only for transmitting sensory information to the cortex and facilitating cortex-cortex communication， but also as an important site of the ascending arousal system， making it a long-standing focus in theoretical investigations into the neural basis of consciousness. A large number of studies have confirmed that the paraventricular thalamic nucleus serves as a key arousal nucleus within the thalamus， featuring extensive connections with brain regions involved in arousal regulation. This article systematically reviews the research progress on the neural mechanisms of the paraventricular thalamic nucleus in sleep-wake regulation and general anesthesia-induced loss of consciousness， aiming to provide a theoretical foundation for clarifying how general anesthetics regulate changes in consciousness.

Key words: paraventricular thalamic nucleus, general anesthesia, arousal

中图分类号:

R614

卢娅丽,陈文佳,柯志丹,周亮. 丘脑室旁核在全身麻醉机制中的研究进展[J]. 实用医学杂志, 2026, 42(5): 892-898.

Yali LU,Wenjia CHEN,Zhidan KE,Liang ZHOU. Research progress of paraventricular nucleus of thalamus in the mechanism of general anesthesia[J]. The Journal of Practical Medicine, 2026, 42(5): 892-898.

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