关键词:

重型颅脑损伤, 肺部感染, 合并症, 抗氧化治疗, 临床疗效

Abstract:

Objective To observe the changes of curative effect indexes of antioxidant therapy in patients with severe craniocerebral injury complicated with bacterial pneumonia. Methods A total of 87 patients with severe craniocerebral injury complicated by pulmonary infection who were admitted to our hospital from February 2020 to February 2022 were prospectively selected. With the informed consent of the patient′s family members，they were randomly divided into control group（n = 45）and observation group（n = 42）according to the odd and even num⁃ bers of the visiting order. The control group was given routine treatment，and the observation group antioxidant therapy on the basis of conventional treatment for 7 consecutive days. WBC，CPR，neutrophil，cell（NEUT）and other inflammatory indicators；blood pH（pH），arterial oxygen saturation（SaO2），oxygenation index（P/F），arterial blood carbon dioxide partial pressure（PaCO2）and other pulmonary ventilation oxidative stress indicators；malondi⁃ aldehyde（MDA），superoxide dismutase（SOD），lipid peroxide（LPO），antioxidant capacity（TAOC），myeloper⁃ oxidase（MPO）and other oxidative stress indicators；and Glasgow coma index（GCS）score before and after the treatment in the two groups were recorded and compared. Results There was no significant difference in GCS score，blood gas index，oxidative stress level and acute infection biochemical index between the two groups before treatment（P > 0.05）. There were statistically significant differences in the two groups before and after the treat⁃ ment（P < 0.01）. WBC，CPR，NEUT，PaCO2，MPO，and LPO in the observation group were lower than those inthe control group（P < 0.01），and the level of pH，SaO2，P/F，SOD，MDA and GCS was significantly higher（P < 0.01）. The level of TAOC was also significantly higher than that of the control group（P < 0.05）after 1 week of treatment. Conclusion The combination of antioxidant drugs in patients with craniocerebral injury and pulmonary infection can effectively improve inflammatory indexes and craniocerebral injury indexes of patients，which has sig⁃ nificant benefits for pulmonary infection and craniocerebral injury，and it is worthy of clinical promotion.

Key words:

severe craniocerebral injury, pulmonary infection, comorbidity, antioxidant, clinical efficacy