自体NK细胞在晚期肾细胞癌治疗中的应用及对患者免疫功能、肿瘤标志物的影响

唐俊天,聂蓬,肖永平,黄颖元,杨云,闫建宏

The application of autologous NK cells in the treatment of advanced renal cell carcinoma and the changes of immune function and tumor markers in patients with advanced renal cell carcinoma

Juntian TANG,Peng NIE,Yongping XIAO,Yingyuan HUANG,Yun YANG,Jianhong YAN

表5 两组免疫功能比较 (x ± s)

Tab.5 Comparison of immune function between the two groups

时间 组别 例数 CD3+/% CD4+/% CD8+/% CD4+/CD8+ NK细胞/（×106/L） 治疗前 靶向组 31 52.69 ± 5.30 30.76 ± 3.62 27.88 ± 3.20 1.10 ± 0.26 167.87 ± 27.50 细胞组 30 52.37 ± 5.44 30.92 ± 3.77 28.15 ± 2.98 1.10 ± 0.31 166.95 ± 26.84 t值 0.233 0.169 0.341 0.000 0.132 P值 0.817 0.866 0.734 1.000 0.895 治疗4个周期后 靶向组 31 54.98 ± 4.92? 35.77 ± 3.59? 26.14 ± 2.16? 1.35 ± 0.29? 228.57 ± 35.40? 细胞组 30 59.80 ± 6.16? 37.86 ± 4.10? 25.98 ± 3.77? 1.46 ± 0.33? 258.03 ± 39.16? t值 3.382 2.120 0.204 1.384 3.084 P值 0.001 0.038 0.839 0.172 0.003