自体NK细胞在晚期肾细胞癌治疗中的应用及对患者免疫功能、肿瘤标志物的影响

唐俊天,聂蓬,肖永平,黄颖元,杨云,闫建宏

The application of autologous NK cells in the treatment of advanced renal cell carcinoma and the changes of immune function and tumor markers in patients with advanced renal cell carcinoma

Juntian TANG,Peng NIE,Yongping XIAO,Yingyuan HUANG,Yun YANG,Jianhong YAN

表4 两组淋巴细胞功能比较 (x ± s）/（pg/mL)

Tab.4 Comparison of lymphocyte function between the two groups

时间 组别 例数 白细胞介素-2 白细胞介素-6 肿瘤坏死因子-β γ干扰素 治疗前 靶向组 31 9.88 ± 2.58 11.97 ± 3.52 4.11 ± 0.87 4.57 ± 0.89 细胞组 30 9.63 ± 3.47 11.68 ± 3.24 4.30 ± 0.95 4.82 ± 0.95 t值 0.320 0.334 0.815 1.061 P值 0.750 0.739 0.418 0.293 治疗4个周期后 靶向组 31 17.40 ± 3.96? 14.89 ± 4.20? 9.84 ± 2.15? 13.37 ± 3.79? 细胞组 30 23.68 ± 4.52? 16.43 ± 4.72? 13.60 ± 3.64? 17.65 ± 5.10? t值 5.777 1.347 4.931 3.729 P值 0.000 0.183 0.000 0.000