自体NK细胞在晚期肾细胞癌治疗中的应用及对患者免疫功能、肿瘤标志物的影响

唐俊天,聂蓬,肖永平,黄颖元,杨云,闫建宏

The application of autologous NK cells in the treatment of advanced renal cell carcinoma and the changes of immune function and tumor markers in patients with advanced renal cell carcinoma

Juntian TANG,Peng NIE,Yongping XIAO,Yingyuan HUANG,Yun YANG,Jianhong YAN

表2 两组血清细胞因子水平比较 (x ± s)

Tab.2 Comparison of serum cytokine levels between the two groups

时间 组别 例数 HIF-1α/（μg/mL） VEGF/（ng/mL） PDGF/（ng/mL） 治疗前 靶向组 31 13.47 ± 3.62 171.26 ± 16.50 37.60 ± 5.84 细胞组 30 13.78 ± 3.90 170.88 ± 17.25 38.44 ± 6.43 t值 0.322 0.088 0.534 P值 0.749 0.930 0.595 治疗4个周期后 靶向组 31 7.15 ± 2.01? 132.90 ± 13.79? 23.97 ± 4.88? 细胞组 30 5.26 ± 0.85? 118.42 ± 12.54? 17.25 ± 3.92? t值 4.754 4.286 5.917 P值 0.000 0.000 0.000